A dose response study of hepatitis A vaccine in healthy adults who are ≤30 years old and weigh ≤77 kg
Document Type
Journal Article
Publication Date
1-1-1998
Journal
Journal of Infectious Diseases
Volume
178
Issue
4
DOI
10.1086/515680
Abstract
The dose response relationship of 25-, 50-, and 100-U doses of an inactivated hepatitis A vaccine was examined in 358-seronegative volunteers in a 2-dose schedule. The 50-U and 100-U groups had statistically significantly higher seroconversion rates than the 25-U group at weeks 2, 4, 8, and 24. Seroconversion was statistically significantly greater for the 100-U compared with the 25- and 50-U doses 2 weeks after the first injection but was not significantly different by 4 weeks after the first injection in the 50- and 100-U dose groups. After 2 injections, all subjects in all groups seroconverted. The vaccine was well tolerated at all dosage levels.
APA Citation
Bertino, J., Thoelen, S., VanDamme, P., Bryan, J., Becherer, P., Frey, S., Hayden, F., Marcus, L., Parenti, D., Sperling, M., Chan, I., Brown, L., & Nalin, D. (1998). A dose response study of hepatitis A vaccine in healthy adults who are ≤30 years old and weigh ≤77 kg. Journal of Infectious Diseases, 178 (4). http://dx.doi.org/10.1086/515680