Effects of anti-inflammatory agents on serum levels of calcitonin precursors during human experimental endotoxemia
Document Type
Journal Article
Publication Date
8-1-2001
Journal
Journal of Infectious Diseases
Volume
184
Issue
3
DOI
10.1086/322031
Abstract
Calcitonin precursor (CTpr) levels are both markers and mediators of inflammation. The duration of their elevation after intravenous endotoxin challenge and the effects of anti-inflammatory therapies were studied in 52 subjects. CTpr levels maximized at 24 h in all subjects. At 7 days (n = 4), after levels of acute-phase cytokines and C-reactive protein had normalized, CTpr levels remained 2-4-fold above baseline levels. The elimination half-life of CTpr levels ranged from 26.9 to 45.7 h. At 24 h, endotoxin and ibuprofen (compared with endotoxin alone) increased CTpr levels ∼2-fold (P = .03), whereas soluble tumor necrosis factor receptor blunted the increase in CTpr levels by 2-3-fold (P = .0015). However, soluble interleukin-1 receptor failed to alter the increase in CTpr levels. Thus, the fact that anti-inflammatory agents may alter CTpr levels resulting from a single stimulus must be considered when CTpr is used as a clinical marker. Of importance, this study reveals that anti-inflammatory agents may modulate the CTpr level, which is a potential toxic mediator of inflammation.
APA Citation
Preas, H., Nylen, E., Snider, R., Becker, K., White, J., Agosti, J., & Suffredini, A. (2001). Effects of anti-inflammatory agents on serum levels of calcitonin precursors during human experimental endotoxemia. Journal of Infectious Diseases, 184 (3). http://dx.doi.org/10.1086/322031