Targeting epigenetics for the treatment of prostate cancer: Recent progress and future directions
Document Type
Journal Article
Publication Date
1-1-2013
Journal
Seminars in Oncology
Volume
40
Issue
3
DOI
10.1053/j.seminoncol.2013.04.010
Abstract
Epigenetic aberrations contribute to prostate cancer carcinogenesis and disease progression. Efforts have been made to target DNA methyltransferase and histone deacetylases (HDACs) in prostate cancer and other solid tumors but have not had the success that was seen in the hematologic malignancies. Oral, less toxic, and more specific agents are being developed in solid tumors including prostate cancer. Combinations of epigenetic agents alone or with a targeted agent such as androgen receptor signaling inhibitors are promising approaches and will be discussed further. © 2013 Elsevier Inc.
APA Citation
Lin, J., Wang, C., & Kelly, W. (2013). Targeting epigenetics for the treatment of prostate cancer: Recent progress and future directions. Seminars in Oncology, 40 (3). http://dx.doi.org/10.1053/j.seminoncol.2013.04.010