The dilemma of a rising prostate-specific antigen level after local therapy: What are our options?
Document Type
Journal Article
Publication Date
6-1-2013
Journal
Seminars in Oncology
Volume
40
Issue
3
DOI
10.1053/j.seminoncol.2013.04.011
Abstract
Prostate cancer is the most common solid tumor diagnosed in men in the United States and Western Europe. Primary treatment with radiation or surgery is largely successful at controlling localized disease. However, a significant number (up to one third of men) may develop biochemical recurrence (BR), defined as a rise in serum prostate-specific antigen (PSA) level. A general presumption is that BR will lead to overt progression in patients over subsequent years. There are a number of factors that a physician must consider when counseling and recommending treatment to a patient with a rising PSA. These include the following (1) various PSA-based definitions of BR; (2) source of PSA (ie, local or distant disease, residual benign prostate); (3) available modalities to treat the disease with the least morbidity; and (4) timing of therapy. In this article we review the current and future factors that clinicians should consider in the diagnosis and treatment of recurrent prostate cancer. © 2013 Elsevier Inc.
APA Citation
Zaorsky, N., Raj, G., Trabulsi, E., Lin, J., & Den, R. (2013). The dilemma of a rising prostate-specific antigen level after local therapy: What are our options?. Seminars in Oncology, 40 (3). http://dx.doi.org/10.1053/j.seminoncol.2013.04.011