"Lipoprotein particle subclasses, cardiovascular disease and HIV infect" by Daniel A. Duprez, Lewis H. Kuller et al.
 

Lipoprotein particle subclasses, cardiovascular disease and HIV infection

Document Type

Journal Article

Publication Date

12-1-2009

Journal

Atherosclerosis

Volume

207

Issue

2

DOI

10.1016/j.atherosclerosis.2009.05.001

Keywords

Atherosclerosis; Cardiovascular disease; Cholesterol; HDL- and LDL-cholesterol; HIV; Ischemic heart disease; Lipids; Lipoprotein particle size and number

Abstract

Objective: To study the association of lipoprotein particles with CVD in a subgroup of HIV-infected patients who were enrolled in the Strategies for Management of Anti-Retroviral Therapy (SMART) study. SMART was a trial of intermittent use of ART (drug conservation [DC]) versus continuous of ART (viral suppression [VS]). Methods: In a nested case-control study, lipoprotein particles (p) by nuclear magnetic resonance were measured at baseline and at the visit prior to the CVD event (latest levels) for 248 patients who had a CVD event and for 480 matched controls. Odds ratios (ORs) were estimated using conditional logistic models. Results: Total, large and small HDL-p, but not VLDL-p nor LDL-p, were significantly and inversely associated with CVD and its major component, non-fatal coronary heart disease. The HDL-p associations with CVD were reduced after adjustment for high sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and D-dimer. Latest levels of total HDL-p were also significantly inversely associated with CVD; treatment interruption led to decrease of total HDL-p; adjusting for latest HDL-p did not explain the greater risk of CVD that was observed in the DC versus VS group. Conclusions: Lipoprotein particles, especially lower levels of small and large HDL-p identify HIV-infected patients at increased risk of CVD independent of other CVD risk factors. © 2009 Elsevier Ireland Ltd.

Plum Print visual indicator of research metrics
PlumX Metrics
  • Citations
    • Citation Indexes: 96
  • Usage
    • Abstract Views: 6
  • Captures
    • Readers: 96
see details

Share

COinS