Further analysis of PREVAIL: Enzalutamide use in chemotherapy-naïve men with metastatic castration-resistant prostate cancer
Document Type
Journal Article
Publication Date
11-1-2014
Journal
Asian Journal of Andrology
Volume
Volume 16, Issue 6
Inclusive Pages
803-804
DOI
10.4103/1008-682X.135129
Abstract
PREVAIL was a phase III multinational, double-blind, placebo-controlled trial that enrolled chemotherapy-naïve men with metastatic castration-resistant prostate cancer (mCRPC), which showed remarkable improvement in co-primary endpoints with an overall 81% reduction in the risk of radiographic progression, as well as 29% reduction in the risk of death in favor of the enzalutamide arm over placebo. All secondary endpoints including time to subsequent chemotherapy initiation and prostate specific antigen (PSA) progression were in favor of the enzalutamide arm. The results of PREVAIL shows the utility of enzalutamide that would likely soon expand the indication to asymptomatic or minimally symptomatic men with mCRPC not previously treated with chemotherapy.
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APA Citation
Aragon-Ching, J.B. (2014). Further analysis of PREVAIL: Enzalutamide use in chemotherapy-naïve men with metastatic castration-resistant prostate cancer. Asian Journal of Andrology, 16(6), 803-804.
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of Asian Journal of Andrology.