Title

Interventions that may influence the course of CAD. Part II: Estrogens and antioxidant vitamins

Document Type

Journal Article

Publication Date

12-1-1995

Journal

Journal of Myocardial Ischemia

Volume

7

Issue

6

Abstract

Observational studies suggest that estrogen markedly decreases risk of First coronary artery disease (CAD) events in postmenopausal women. This protective effect may be even stronger in women who already have CAD. A recent randomized trial showed favorable effects of unopposed estrogen and estrogen-progestin combinations on the cardiovascular (CV) risk profile. Although no increase in breast or endometrial cancer was noted, an excess in endometrial hyperplasia or hysterectomy was observed in women taking unopposed estrogen. Considerable epidemiologic data support a protective role of dietary antioxidants against CAD. Also, two prospective studies, one in men and the other in women, showed that high vitamin E intake reduces the risk of CAD, and the study in men also showed a protective effect of beta-carotene, especially in smokers. Further clinical trials are needed to confirm the results with these treatments.

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