Title

Separation and study of the range of plasminogen isoforms in patients with prostate cancer

Document Type

Journal Article

Publication Date

9-1-2012

Journal

Biochemistry (Moscow)

Volume

77

Issue

9

DOI

10.1134/S0006297912090143

Keywords

MALDI-TOF-MS; Plasminogen isoforms; Prostate cancer; Two-dimensional electrophoresis

Abstract

Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plas- minogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in var- ious stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and high- er pI values compared to isoforms found in the control group. © Pleiades Publishing, Ltd., 2012.

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