Separation and study of the range of plasminogen isoforms in patients with prostate cancer
MALDI-TOF-MS; Plasminogen isoforms; Prostate cancer; Two-dimensional electrophoresis
Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plas- minogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in var- ious stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and high- er pI values compared to isoforms found in the control group. © Pleiades Publishing, Ltd., 2012.
Shin, E., Vodolazhsky, D., Golikov, A., Belova, T., Boyko, N., Zimakov, D., Cherkasova, E., Kogan, M., Chibichian, M., Moshkovskii, S., Tarasov, V., & Matishov, D. (2012). Separation and study of the range of plasminogen isoforms in patients with prostate cancer. Biochemistry (Moscow), 77 (9). http://dx.doi.org/10.1134/S0006297912090143