Separation and study of the range of plasminogen isoforms in patients with prostate cancer

Authors

E. F. Shin, Institute of Arid Zones SSC RAS
D. I. Vodolazhsky, Institute of Arid Zones SSC RAS
A. Y. Golikov, Institute of Arid Zones SSC RAS
T. N. Belova, Institute of Arid Zones SSC RAS
N. V. Boyko, Institute of Arid Zones SSC RAS
D. V. Zimakov, Institute of Arid Zones SSC RAS
E. N. Cherkasova, Institute of Arid Zones SSC RAS
M. I. Kogan, Rostov State Medical University
M. B. Chibichian, Rostov State Medical University
S. A. Moshkovskii, V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
V. A. Tarasov, Institute of Arid Zones SSC RAS
D. G. Matishov, Institute of Arid Zones SSC RAS

Document Type

Journal Article

Publication Date

9-1-2012

Journal

Biochemistry (Moscow)

Volume

77

Issue

9

DOI

10.1134/S0006297912090143

Keywords

MALDI-TOF-MS; Plasminogen isoforms; Prostate cancer; Two-dimensional electrophoresis

Abstract

Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plas- minogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in var- ious stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and high- er pI values compared to isoforms found in the control group. © Pleiades Publishing, Ltd., 2012.

APA Citation

Shin, E., Vodolazhsky, D., Golikov, A., Belova, T., Boyko, N., Zimakov, D., Cherkasova, E., Kogan, M., Chibichian, M., Moshkovskii, S., Tarasov, V., & Matishov, D. (2012). Separation and study of the range of plasminogen isoforms in patients with prostate cancer. Biochemistry (Moscow), 77 (9). http://dx.doi.org/10.1134/S0006297912090143