The genetic as pects of endothelial dysfunction in patients with type 2 diabetes mellitus
Medical News of North Caucasus
379del polymorphism in eNOS3 gene; Diabetes mellitus; Endothelial dysfunction; Endothelium-dependent vasodilation; Markers of endothelial dysfunction; S.582+353
The severity of cardiovascular complications of diabetes mellitus (DM) is subject to numerous factors, including genetic. The aim of the study was to evaluate the effect of s.582+353-379del polymorphism in the endothelial nitric oxide synthase (eNOS3) gene on endothelial function in men with type 2 DM. We examined 144 men with type 2 DM aged 40-65 years. Patients were divided into two groups according to the presence or absence of s.582+353-379del polymorphism in the eNOS3 gene. In patients with the presence of deletion in the 27 pair of nucleotides in intron 4 of the eNOS gene decreased concentrations of nitric oxide, as well as a significant reduction of eNOS3 activity were detected along with the increase of endothelin, VCAM-1, ICAM-1 and E-selectin concentrations which indicates the endothelial dysfunction development. In patients with type 2 DM with s.582+353-379del polymorphism of eNOS3 gene the diameter of the brachial artery during vasodilation was decreased and the severity of endothelium-dependent vasodilation of blood vessels was reduced, which is the clinical manifestation of endothelial dysfunction potentially dangerous in terms of the vascular complications of DM progression.
Khripun, I., Vorobyev, S., Morgunov, M., Belousov, I., Dzantieva, E., Gusova, Z., Ibishev, H., & Kogan, M. (2015). The genetic as pects of endothelial dysfunction in patients with type 2 diabetes mellitus. Medical News of North Caucasus, 10 (4). http://dx.doi.org/10.14300/mnnc.2015.10083