The genetic as pects of endothelial dysfunction in patients with type 2 diabetes mellitus

Document Type

Journal Article

Publication Date

1-1-2015

Journal

Medical News of North Caucasus

Volume

10

Issue

4

DOI

10.14300/mnnc.2015.10083

Keywords

379del polymorphism in eNOS3 gene; Diabetes mellitus; Endothelial dysfunction; Endothelium-dependent vasodilation; Markers of endothelial dysfunction; S.582+353

Abstract

The severity of cardiovascular complications of diabetes mellitus (DM) is subject to numerous factors, including genetic. The aim of the study was to evaluate the effect of s.582+353-379del polymorphism in the endothelial nitric oxide synthase (eNOS3) gene on endothelial function in men with type 2 DM. We examined 144 men with type 2 DM aged 40-65 years. Patients were divided into two groups according to the presence or absence of s.582+353-379del polymorphism in the eNOS3 gene. In patients with the presence of deletion in the 27 pair of nucleotides in intron 4 of the eNOS gene decreased concentrations of nitric oxide, as well as a significant reduction of eNOS3 activity were detected along with the increase of endothelin, VCAM-1, ICAM-1 and E-selectin concentrations which indicates the endothelial dysfunction development. In patients with type 2 DM with s.582+353-379del polymorphism of eNOS3 gene the diameter of the brachial artery during vasodilation was decreased and the severity of endothelium-dependent vasodilation of blood vessels was reduced, which is the clinical manifestation of endothelial dysfunction potentially dangerous in terms of the vascular complications of DM progression.

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