Prognostic markers of recurrence of prostate cancer after radical prostatectomy

Document Type

Journal Article

Publication Date

1-1-2016

Journal

Medical News of North Caucasus

Volume

11

Issue

4

DOI

10.14300/mnnc.2016.11120

Keywords

Angiotensin converting enzyme; Biochemical recurrence; Prognostic markers; Prostate cancer; Radical prostatectomy

Abstract

The study identified markers for the prediction of aggressive forms of prostate cancer. The study included 59 patients with prostate cancer who underwent radical prostatectomy, followed by PSA monitoring after 1, 6, 12 and 18 months after surgery. For identification of prostate cancer progression associated index the activity of angiotensinconverting enzyme (ACE) was determined in the serum. The recurrence of prostate cancer was associated with an increase in ACE activity. At the same time, ACE activity was beginning to rise before the development of biochemical recurrence. Joint determination of PSA and the activity of ACE after 1 month after surgery made it possible to identify a group of patients at high risk for biochemical recurrence with a sensitivity and specificity - 72.7 % (p<0.001) and 91.2 % (p<0.001), respectively. Thus, ACE is a promising prognostic marker of clinically aggressive forms of prostate cancer. Renin-angiotensin system of the organism in prostate cancer can be treated as a new therapeutic "target" for targeted therapy.

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