Title

Role of angiotensin II receptor type 2 in predicting biochemical recurrence in the treatment of prostate cancer

Document Type

Journal Article

Publication Date

12-1-2016

Journal

Urologiia (Moscow, Russia : 1999)

Issue

6

Keywords

angiotensin II type 2 receptors; biochemical recurrence; hormone and radiation therapy; prostate cancer; the renin-angiotensin system; tumor markers

Abstract

AIM: To identify markers for predicting aggressive forms of prostate cancer.MATERIALS AND METHODS: The study retrospectively evaluated expression of angiotensin II type 2 receptors (AT2-R) in prostate needle biopsy tissue from patients with and without biochemical recurrence after combined hormone and radiation therapy.RESULTS: The study findings showed that low expression of AT2-R in prostate tissue was associated with a high risk of biochemical recurrence. The data on the nature of AT2-R expression in prostate tissue of prostate cancer patients may be considered as a tool for predicting biochemical recurrence after combined hormone and radiation therapy. The test has a sensitivity of 87.5% and specificity of 85.71%.

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