Role of angiotensin II receptor type 2 in predicting biochemical recurrence in the treatment of prostate cancer

Authors

M. B. Chibichyan, Rostov Regional Pathological Anatomical Bureau
M. I. Kogan, Rostov Regional Pathological Anatomical Bureau
E. A. Chernogubova, Rostov Regional Pathological Anatomical Bureau
I. A. Pavlenko, Rostov Regional Pathological Anatomical Bureau
D. G. Matishov, Rostov Regional Pathological Anatomical Bureau

Document Type

Journal Article

Publication Date

12-1-2016

Journal

Urologiia (Moscow, Russia : 1999)

Issue

6

Keywords

angiotensin II type 2 receptors; biochemical recurrence; hormone and radiation therapy; prostate cancer; the renin-angiotensin system; tumor markers

Abstract

AIM: To identify markers for predicting aggressive forms of prostate cancer.MATERIALS AND METHODS: The study retrospectively evaluated expression of angiotensin II type 2 receptors (AT2-R) in prostate needle biopsy tissue from patients with and without biochemical recurrence after combined hormone and radiation therapy.RESULTS: The study findings showed that low expression of AT2-R in prostate tissue was associated with a high risk of biochemical recurrence. The data on the nature of AT2-R expression in prostate tissue of prostate cancer patients may be considered as a tool for predicting biochemical recurrence after combined hormone and radiation therapy. The test has a sensitivity of 87.5% and specificity of 85.71%.

APA Citation

Chibichyan, M., Kogan, M., Chernogubova, E., Pavlenko, I., & Matishov, D. (2016). Role of angiotensin II receptor type 2 in predicting biochemical recurrence in the treatment of prostate cancer. Urologiia (Moscow, Russia : 1999), (6). Retrieved from https://hsrc.himmelfarb.gwu.edu/smhs_medicine_facpubs/4415