Efficacies of four antifungal agents in experimental murine sporotrichosis

Authors

V. L. Kan, National Institute of Allergy and Infectious Diseases (NIAID)
J. E. Bennett, National Institute of Allergy and Infectious Diseases (NIAID)

Document Type

Journal Article

Publication Date

1-1-1988

Journal

Antimicrobial Agents and Chemotherapy

Volume

32

Issue

11

DOI

10.1128/AAC.32.11.1619

Abstract

Four antifungal agents, amphotericin B, SDZ 89-485, itraconazole, and terbinafine, were tested for efficacy in a murine model of systemic sporotrichosis. Survival in the groups treated with amphotericin B, SDZ 89-485, and itraconazole was significantly better than that of control infected mice. However, these agents did not wholly protect the infected mice, as tail and paw lesions, whole-body radiographs, and positive cultures from survivors showed evidence of dissemination. Terbinafine-treated mice had the same or poorer survival as control infected mice, despite documented drug absorption.

APA Citation

Kan, V., & Bennett, J. (1988). Efficacies of four antifungal agents in experimental murine sporotrichosis. Antimicrobial Agents and Chemotherapy, 32 (11). http://dx.doi.org/10.1128/AAC.32.11.1619