Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion
Antimicrobial Agents and Chemotherapy
The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14α- demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.
Kan, V., Geber, A., & Bennett, J. (1996). Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion. Antimicrobial Agents and Chemotherapy, 40 (7). http://dx.doi.org/10.1128/aac.40.7.1717