Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion

Document Type

Journal Article

Publication Date

1-1-1996

Journal

Antimicrobial Agents and Chemotherapy

Volume

40

Issue

7

DOI

10.1128/aac.40.7.1717

Abstract

The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14α- demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.

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