Durable neutralizing antibodies after remote smallpox vaccination among adults with and without HIV infection
Document Type
Journal Article
Publication Date
2-1-2007
Journal
AIDS
Volume
21
Issue
4
DOI
10.1097/QAD.0b013e32802f7d7c
Abstract
The only US licensed vaccine with established efficacy against smallpox, Dryvax, is contraindicated for HIV patients. Detectable smallpox-neutralizing antibodies are still present among US adults. This study compared vaccinia-neutralizing antibody titers between 20 HIV-infected and 20 uninfected veterans matched for age and military entry. Vaccinia-neutralizing antibodies were detected in 95% HIV-infected and 100% uninfected veterans; 40% HIV-infected and 70% uninfected adults had protective titers. Therefore, after robust vaccination, neutralizing antibodies are maintained for prolonged times despite CD4 cell depletion. © 2007 Lippincott Williams & Wilkins, Inc.
APA Citation
Kan, V., Manischewitz, J., King, L., & Golding, H. (2007). Durable neutralizing antibodies after remote smallpox vaccination among adults with and without HIV infection. AIDS, 21 (4). http://dx.doi.org/10.1097/QAD.0b013e32802f7d7c
