The dopaminergic system in hypertension
Document Type
Journal Article
Publication Date
6-1-2007
Journal
Clinical Science
Volume
112
Issue
11-12
DOI
10.1042/CS20070018
Keywords
Artery; Blood pressure; Central nervous system; Dopamine receptor; Hypertension; Kidney; Sodium homoeostasis
Abstract
Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport, vascular smooth muscle contractility and production of reactive oxygen species and by interacting with the renin-angiotensin and sympathetic nervous systems. Dopamine receptors are classified into D1-like (D1 and D5) and D 2-like (D2, D3 and D4) subtypes based on their structure and pharmacology. Each of the dopamine receptor subtypes participates in the regulation of blood pressure by mechanisms specific for the subtype. Some receptors regulate blood pressure by influencing the central and/or peripheral nervous system; others influence epithelial transport and regulate the secretion and receptors of several humoral agents. This review summarizes the physiology of the different dopamine receptors in the regulation of blood pressure, and the relationship between dopamine receptor subtypes and hypertension. © The Authors.
APA Citation
Zeng, C., Zhang, M., Asico, L., Eisner, G., & Jose, P. (2007). The dopaminergic system in hypertension. Clinical Science, 112 (11-12). http://dx.doi.org/10.1042/CS20070018