Title

Dopamine, kidney, and hypertension: Studies in dopamine receptor knockout mice

Document Type

Journal Article

Publication Date

7-11-2008

Journal

Pediatric Nephrology

Volume

23

Issue

12

DOI

10.1007/s00467-008-0901-3

Keywords

Dopamine receptor; Hypertension; Knockout mice; Renal function

Abstract

Dopamine is important in the pathogenesis of hypertension because of abnormalities in receptor-mediated regulation of renal sodium transport. Dopamine receptors are classified into D1-like (D1, D5) and D2-like (D2, D3, D4) subtypes, all of which are expressed in the kidney. Mice deficient in specific dopamine receptors have been generated to provide holistic assessment on the varying physiological roles of each receptor subtype. This review examines recent studies on these mutant mouse models and evaluates the impact of individual dopamine receptor subtypes on blood pressure regulation. © IPNA 2008.

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