Dopamine, kidney, and hypertension: Studies in dopamine receptor knockout mice
Document Type
Journal Article
Publication Date
7-11-2008
Journal
Pediatric Nephrology
Volume
23
Issue
12
DOI
10.1007/s00467-008-0901-3
Keywords
Dopamine receptor; Hypertension; Knockout mice; Renal function
Abstract
Dopamine is important in the pathogenesis of hypertension because of abnormalities in receptor-mediated regulation of renal sodium transport. Dopamine receptors are classified into D1-like (D1, D5) and D2-like (D2, D3, D4) subtypes, all of which are expressed in the kidney. Mice deficient in specific dopamine receptors have been generated to provide holistic assessment on the varying physiological roles of each receptor subtype. This review examines recent studies on these mutant mouse models and evaluates the impact of individual dopamine receptor subtypes on blood pressure regulation. © IPNA 2008.
APA Citation
Wang, X., Villar, V., Armando, I., Eisner, G., Felder, R., & Jose, P. (2008). Dopamine, kidney, and hypertension: Studies in dopamine receptor knockout mice. Pediatric Nephrology, 23 (12). http://dx.doi.org/10.1007/s00467-008-0901-3