Immunity in human schistosomiasis: Hope for a vaccine

Authors

B. Kouriba, University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology
B. Traore, University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology
D. Diemert, The George Washington University
M. A. Thera, University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology
A. Dolo, University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology
A. Tounkara, Project SEREFO (Centre de Recherche et de Formation sur le VIH/Sida et la Tuberculose)/University of Sciences
O. Doumbo, University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology

Document Type

Journal Article

Publication Date

4-1-2010

Journal

Medecine Tropicale

Volume

70

Issue

2

Keywords

Immunity; Immunopathology; Schistosoma; Vaccine

Abstract

Schistosomiasis remains a major worldwide public health problem in several endemic areas despite implementation of control measures. Vaccination would be an effective, long-term treatment option for future control of schistosomiasis. Although several parasite antigens have been identified as schistosomiasis vaccine candidates, major hurdles must still be overcome to develop a vaccine suitable for clinical trials in the field. Better understanding of immune responses to Schistosoma infection in both animal models and humans suggests that development of a vaccine is possible. The purpose of this review is to summarize the mechanisms of protective immunity against Schistosoma infection and to provide perspective on the development of a vaccine.

APA Citation

Kouriba, B., Traore, B., Diemert, D., Thera, M., Dolo, A., Tounkara, A., & Doumbo, O. (2010). Immunity in human schistosomiasis: Hope for a vaccine. Medecine Tropicale, 70 (2). Retrieved from https://hsrc.himmelfarb.gwu.edu/smhs_medicine_facpubs/3546