Molecular aberrations and signaling cascades implicated in the pathogenesis of anaplastic thyroid cancer
Document Type
Journal Article
Publication Date
12-1-2019
Journal
Biochimica et Biophysica Acta - Reviews on Cancer
Volume
1872
Issue
2
DOI
10.1016/j.bbcan.2018.12.003
Keywords
Anaplastic thyroid cancer; Inhibitors; Mutations; Signaling; Therapeutics; Tumor
Abstract
© 2019 Anaplastic Thyroid Cancer (ATC) accounts for >40% thyroid cancer-related deaths and has a dismal prognosis. In the past decade, significant efforts have been made towards understanding the pathogenesis of this disease and developing novel therapeutics. Unfortunately, effective treatment is still lacking and a more thorough understanding of ATC pathogenesis may provide new opportunities to improve ATC therapeutics. This review provides insights into ATC clinical presentation and pathology, and the putative role of genetic aberrations and alterations in molecular signaling pathways in ATC pathogenesis. We reviewed prevalent mutations, chromosomal abnormalities and fusions, epigenetic alterations and dysregulations in ATC, and highlighted several signaling cascades which appeared to be integral to ATC pathogenesis. Moreover, these features offer insights into de-differentiated, aggressive and drug-resistant phenotype of ATC, and thus may help in exploring potential new molecular targets for developing novel therapeutics.
APA Citation
Saini, S., Maker, A., Burman, K., & Prabhakar, B. (2019). Molecular aberrations and signaling cascades implicated in the pathogenesis of anaplastic thyroid cancer. Biochimica et Biophysica Acta - Reviews on Cancer, 1872 (2). http://dx.doi.org/10.1016/j.bbcan.2018.12.003