Prevalence of positive QuantiFERON gold in-tube testing in hidradenitis suppurativa.

Document Type

Journal Article

Publication Date

9-1-2018

Journal

The Journal of dermatological treatment

Volume

29

Issue

6

DOI

10.1080/09546634.2018.1425360

Keywords

Adult; False Positive Reactions; Female; Hidradenitis Suppurativa; Humans; Latent Tuberculosis; Male; Middle Aged; Prevalence; Prospective Studies; Reagent Kits, Diagnostic; Tuberculin Test

Abstract

AIM: Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of the apocrine sweat glands. Tumor necrosis factor-alpha (TNF-α) inhibitors are commonly used to treat HS. However, prior to initiating therapy patients must be screened for mycobacterium tuberculosis (mTB) exposure. Several mTB screening tests based on interferon gamma release assays are commercially available, but the performance of these assays in the HS population is unknown. The purpose of this study was to investigate the performance of the QuantiFERON gold in-tube assay (QFT-GIT) in a cohort of patients with HS.

METHODS: This prospective study was conducted through the Wound Etiology and Healing (WE-HEAL) study. QFTGIT testing was performed using a commercial laboratory. Patients with positive test results underwent follow-up testing to evaluate for latent tuberculosis infection (LTBI). Data were collected on demographics and disease activity scores including Hurley stage, HS Sartorius score (HSS) and active nodule (AN) count.

RESULTS: Of the 69 patients with a confirmed diagnosis of HS, seven (10.1%) tested QFT-GIT positive and 5.8% were diagnosed with LTBI.

CONCLUSIONS: QFT-GIT results did not correlate with demographic characteristics or HS disease activity.

Comments

This is an open access PubMed Central article.

Peer Reviewed

1

Open Access

1

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