Document Type
Journal Article
Publication Date
8-2013
Journal
Clinical Medical Insights - Oncology
Volume
Volume 7
Inclusive Pages
235-245
DOI
10.4137/CMO.S11670
Abstract
Enzalutamide, previously known as MDV300, is an oral, second-generation androgen receptor (AR) signaling inhibitor or antagonist that was approved by the Food and Drug Administration in 2012 for the treatment of metastatic castrate-resistant prostate cancer (mCRPC) postdocetaxel. Preclinical studies have demonstrated impressive affinity to the AR compared to the first-generation AR inhibitors. The landmark Phase III AFFIRM trial demonstrated improved overall survival benefit compared to placebo in addition to improvement in all tested parameters. Enzalutamide is currently being studied in several trials prechemotherapy and in earlier settings of prostate cancer. This review will discuss the mechanism of action of enzalutamide, its pharmacokinetics, the preclinical and clinical trials that led to its approval, the ongoing clinical trials, its safety and efficacy, as well as patterns of resistance, and discusses its place in therapy within the context of several recently approved agents for mCRPC.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License
APA Citation
El-Amm, J., Patel, N., Freeman, A., Aragon-Ching, J.B. (2013). Metastatic castration-resistant prostate cancer: Critical review of enzalutamide. Clinical Medical Insights - Oncology, 7:235-345.
Peer Reviewed
1
Open Access
1
Comments
This article has an erratum.
Reproduced with permission of Libertas Academica, Clinical Medical Insights.