Document Type
Journal Article
Publication Date
2013
Journal
Open Hypertension Journal
Volume
Volume 5
Inclusive Pages
12-17
Abstract
The discovery of endothelin created a lot of enthusiasm and paved new therapeutic avenues for the treatment of arterial hypertension. Endothelin plays a significant role in blood pressure regulation through pronounced vasoconstriction and modulation of sodium and water reabsorption in the kidneys. Endothelin receptor antagonists have been tested in many clinical trials in patients with arterial hypertension, heart failure, pulmonary arterial hypertension, systemic sclerosis, chronic kidney disease, and diabetic nephropathy. However, the results were usually disappointing, except in pulmonary hypertension and scleroderma digital ulcers. The future of ERAs for the treatment of arterial hypertension and chronic kidney disease does not seem bright, and only the combination with other classes of antihypertensive drugs might offer a way out.
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
APA Citation
Doumas, M., Athyros, V., Katsiki, N., Reklou,A., Lazaridis, A., Karagiannis, A. (2013). Endothelin receptor antagonists (ERA) in hypertension and chronic kidney disease: A rose with many thorns. Open Hypertension Journal, 5, 12-17.
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of Bentham Science Publishers, Open Hypertension Journal.