Document Type
Journal Article
Publication Date
6-14-2016
Journal
Oncotarget
DOI
10.18632/oncotarget.10034
Abstract
There is no curative treatment for patients with diffuse intrinsic pontine glioma (DIPG). However, with the recent availability of biopsy and autopsy tissue, new data regarding the biologic behavior of this tumor have emerged, allowing greater molecular characterization and leading to investigations which may result in improved therapeutic options. Treatment strategies must address both primary disease sites as well as any metastatic deposits, which may be variably sensitive to a particular approach.In this case report, we present a patient with DIPG treated with irradiation and serial investigational agents. The clinical, pathological and molecular phenotypes of both the progressive primary tumor as well as concomitant metastatic deposits obtained at autopsy are discussed. While some mRNA differences were demonstrated, all analyzed sites of disease shared similar mutational arrangements, suggesting that targeting the mutations of the primary tumor may be effective for all sites of disease.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Nazarian, J., Mason, G., Ho, C., Panditharatna, E., Kambhampati, M., Vezina, L. G., Packer, R. J., & Hwang, E. (2016). Histological and molecular analysis of a progressive diffuse intrinsic pontine glioma and synchronous metastatic lesions: a case report.. Oncotarget, (). http://dx.doi.org/10.18632/oncotarget.10034
Peer Reviewed
1
Open Access
1
Included in
Integrative Biology Commons, Oncology Commons, Pathology Commons, Systems Biology Commons
Comments
Reproduced with permission of Impact Journals, LLC. Oncotarget.