Document Type
Journal Article
Publication Date
1-1-2016
Journal
PLoS One
Volume
11
Issue
1
Inclusive Pages
e0148112
DOI
10.1371/journal.pone.0148112
Abstract
Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a 12 week unilateral arm RT program. Maximum voluntary contraction (MVC) assessed isometric strength (kg) and MRI assessed biceps size (cm2) pre- and post-resistance training. Subjects were genotyped for NR3C1 -2722G>A, -1887G>A, -1017T>C, and +363A>G. Men carrying the -2722G allele gained less relative MVC (17.3±1.2vs33.5±6.1%) (p = 0.010) than AA homozygotes; men with -1887GG gained greater relative MVC than A allele carriers (19.6±1.4vs13.2±2.3%) (p = 0.016). Women carrying the -1017T allele gained greater relative size (18.7±0.5vs16.1±0.9%) (p = 0.016) than CC homozygotes. We found sex-specific NR3C1 associations with the muscle strength and size response to RT. Future studies should investigate whether these associations are partially explained by cortisol's actions in muscle tissue as they interact with sex differences in cortisol production.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Ash, G., Kostek, M., Lee, H., Angelopoulos, T., Clarkson, P., Gordon, P., Moyna, N., Visich, P., Zoeller, R., Price, T., Devaney, J. M., Gordish-Dressman, H., Thompson, P., Hoffman, E. P., & Pescatello, L. (2016). Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training.. PLoS One, 11 (1). http://dx.doi.org/10.1371/journal.pone.0148112
Peer Reviewed
1
Open Access
1
Included in
Integrative Biology Commons, Systems and Integrative Physiology Commons, Systems Biology Commons
Comments
Reproduced with permission of PLoS ONE.