Document Type
Journal Article
Publication Date
2014
Journal
DARU Journal of Pharmaceutical Sciences
Volume
Volume 22
Inclusive Pages
Article number 36
Abstract
Poison-induced cardiogenic shock (PICS) as a result of beta-blocker (?-blocker) or calcium channel blocker (CCB) overdose is a common and potentially life-threatening condition. Conventional therapies, including fluid resuscitation, atropine, cardiac pacing, calcium, glucagon, and vasopressors often fail to improve hemodynamic status. High-dose insulin (HDI) is an emerging therapeutic modality for PICS. In this article, we discuss the existing literature and highlight the therapeutic success and potential of HDI. Based on the current literature, which is limited primarily to case series and animal models, the authors conclude that HDI can be effective in restoring hemodynamic stability, and recommend considering its use in patients with PICS that is not responsive to traditional therapies. Future studies should be undertaken to determine the optimal dose and duration of therapy for HDI in PICS.
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
APA Citation
Woodward, C., Pourmand, A., Mazer-Amirshahi, M. (2014). High dose insulin therapy, an evidence based approach to beta blocker/calcium channel blocker toxicity. DARU Journal of Pharmaceutical Sciences, 22:36.
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of BioMed Central DARU Journal of Pharmaceutical Sciences.