Topical Agents for the Treatment of Atopic Dermatitis
Document Type
Journal Article
Publication Date
1-1-2020
Journal
Journal of drugs in dermatology : JDD
Volume
19
Issue
1
DOI
10.36849/JDD.2020.4508
Abstract
Approval of the new topical phosphodiesterase 4 inhibitor crisaborole ointment, 2%, to treat mild-to-moderate atopic dermatitis (AD) warrants careful consideration of available efficacy and safety data for topical therapies to contribute to a better understanding of the role of crisaborole in the treatment of mild-to-moderate AD. A literature review was conducted to identify results of randomized, blinded, vehicle-controlled trials of topical agents for the treatment of AD published from January 1, 1997 to April 30, 2018. This review summarizes the efficacy and safety data of topical therapies including corticosteroids, calcineurin inhibitors, and crisaborole and it shows that comparison among available agents is difficult because of differing methodologies used across clinical trials and that there is considerable variability in safety reporting among AD trials. Published clinical studies for crisaborole demonstrate its efficacy and manageable safety profile. J Drugs Dermatol. 2020;19(1):50-64. doi:10.36849/JDD.2020.4508
APA Citation
Eichenfield, L., Luger, T., Papp, K., Silverberg, J., Sierka, D., Zang, C., Tallman, A., Zielinski, M., & Ports, W. (2020). Topical Agents for the Treatment of Atopic Dermatitis. Journal of drugs in dermatology : JDD, 19 (1). http://dx.doi.org/10.36849/JDD.2020.4508