Mycobacterium tuberculosis CDC1551 is resistant to reactive nitrogen and oxygen intermediates in vitro
Document Type
Journal Article
Publication Date
7-2-2002
Journal
Infection and Immunity
DOI
10.1128/iai.70.7.3965-3968.2002
Abstract
Resistance to reactive oxygen intermediates and reactive nitrogen intermediates in vitro of a clinical isolate of Mycobacterium tuberculosis (CDC1551) that caused a large outbreak of tuberculosis was compared to that of M. tuberculosis strains CB3.3, H37Rv, H37Ra, Erdman, RJ2E, C.C. 13, and C.C. 22 as well as M. boris strains Ravenel and BCG. CDC1551 and CB3.3 were significantly more resistant to both hydrogen peroxide (H2O2) and acidified sodium nitrite than were the other strains tested. This biological phenotype may serve as an in vitro marker for clinical strains of M. tuberculosis likely to cause a large outbreak of tuberculosis.
Recommended Citation
Firmani, Marcia A. and Riley, Lee W., "Mycobacterium tuberculosis CDC1551 is resistant to reactive nitrogen and oxygen intermediates in vitro" (2002). Biomedical Laboratory Sciences Faculty Publications. Paper 14.
https://hsrc.himmelfarb.gwu.edu/smhs_biomed_facupubs/14
Peer Reviewed
1
Open Access
1
Comments
This is an open access PubMed Central article.