Perioperative Applications of Therapeutic Plasma Exchange in Cardiac Surgery: A Narrative Review

Authors

Alison Grazioli, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Janhavi Athale, National Institutes of Health (NIH)
Kenichi Tanaka, University of Maryland School of Medicine
Ronson Madathil, University of Maryland School of Medicine
Joseph Rabin, University of Maryland School of Medicine
David Kaczorowski, University of Maryland School of Medicine
Michael Mazzeffi, University of Maryland School of Medicine

Document Type

Journal Article

Publication Date

12-1-2020

Journal

Journal of Cardiothoracic and Vascular Anesthesia

Volume

34

Issue

12

DOI

10.1053/j.jvca.2020.01.054

Keywords

cardiac surgery; coagulation; immunology; plasma exchange

Abstract

Therapeutic plasma exchange (TPE) has a number of applications in cardiac surgical patients and has been used increasingly in high-risk heart and lung transplant patients. In this narrative review, the authors describe TPE principles, complications, and specific indications for TPE, including thrombotic thrombocytopenic purpura, heparin-induced thrombocytopenia, induction of immunotolerance in heart and lung transplant patients, and treatment of antibody-mediated rejection in heart and lung transplant patients. The review is based on published literature and the authors’ institutional experience with perioperative TPE in cardiac surgical patients.

APA Citation

Grazioli, A., Athale, J., Tanaka, K., Madathil, R., Rabin, J., Kaczorowski, D., & Mazzeffi, M. (2020). Perioperative Applications of Therapeutic Plasma Exchange in Cardiac Surgery: A Narrative Review. Journal of Cardiothoracic and Vascular Anesthesia, 34 (12). http://dx.doi.org/10.1053/j.jvca.2020.01.054