Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series
Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated protein C. To our knowledge, there is only 1 prior study of factor VIII and functional protein C activity in critically ill patients with COVID-19. Here, we present a case series of 10 critically ill patients with COVID-19 who had severe elevations in factor VIII activity and low normal functional protein C activity, which may have contributed to hypercoagulability.
Tabatabai, A., Rabin, J., Menaker, J., Madathil, R., Galvagno, S., Menne, A., Chow, J., Grazioli, A., Herr, D., Tanaka, K., Scalea, T., & Mazzeffi, M. (2020). Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series. A&A practice, 14 (7). http://dx.doi.org/10.1213/XAA.0000000000001236