Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series

Authors

Ali Tabatabai, Adams Cowley Shock Trauma Center
Joseph Rabin, Adams Cowley Shock Trauma Center
Jay Menaker, Adams Cowley Shock Trauma Center
Ronson Madathil, Division of Cardiothoracic Surgery
Samuel Galvagno
Ashley Menne, University of Maryland School of Medicine
Jonathan H. Chow
Alison Grazioli, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Daniel Herr, Adams Cowley Shock Trauma Center
Kenichi Tanaka
Thomas Scalea, Adams Cowley Shock Trauma Center
Michael Mazzeffi

Document Type

Journal Article

Publication Date

5-1-2020

Journal

A&A practice

Volume

14

Issue

7

DOI

10.1213/XAA.0000000000001236

Abstract

Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated protein C. To our knowledge, there is only 1 prior study of factor VIII and functional protein C activity in critically ill patients with COVID-19. Here, we present a case series of 10 critically ill patients with COVID-19 who had severe elevations in factor VIII activity and low normal functional protein C activity, which may have contributed to hypercoagulability.

APA Citation

Tabatabai, A., Rabin, J., Menaker, J., Madathil, R., Galvagno, S., Menne, A., Chow, J., Grazioli, A., Herr, D., Tanaka, K., Scalea, T., & Mazzeffi, M. (2020). Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series. A&A practice, 14 (7). http://dx.doi.org/10.1213/XAA.0000000000001236