Document Type
Journal Article
Publication Date
2012
Journal
PLoS ONE
Volume
Volume 7, Issue 2
Inclusive Pages
Article number e32029
Keywords
Brain--drug effects; Carbon Monoxide--toxicity; Learning Disorders--chemically induced; Memory Disorders--chemically induced
Abstract
Carbon monoxide (CO) exposure at high concentrations results in overt neurotoxicity. Exposure to low CO concentrations occurs commonly yet is usually sub-clinical. Infants are uniquely vulnerable to a variety of toxins, however, the effects of postnatal sub-clinical CO exposure on the developing brain are unknown. Apoptosis occurs normally within the brain during development and is critical for synaptogenesis. Here we demonstrate that brief, postnatal sub-clinical CO exposure inhibits developmental neuroapoptosis resulting in impaired learning, memory, and social behavior. Three hour exposure to 5 ppm or 100 ppm CO impaired cytochrome c release, caspase-3 activation, and apoptosis in neocortex and hippocampus of 10 day old CD-1 mice. CO increased NeuN protein, neuronal numbers, and resulted in megalencephaly. CO-exposed mice demonstrated impaired memory and learning and reduced socialization following exposure. Thus, CO-mediated inhibition of neuroapoptosis might represent an important etiology of acquired neurocognitive impairment and behavioral disorders in children.
APA Citation
Cheng, Y., Thomas, A., Mardini, F., Bianchi, S.L., Tang, J.X., Peng, J., Wei, H., Eckenhoff, M.F., Eckenhoff, R.G., Levy, R.J. (2012). Neurodevelopmental consequences of sub-clinical carbon monoxide exposure in newborn mice. PLoS ONE, 7(2), e32029.
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of PLoS ONE.