Document Type
Journal Article
Publication Date
2-2015
Journal
Critical care
Volume
19
Inclusive Pages
Article number 93
DOI
10.1186/s13054-015-0779-y
Keywords
Acute Kidney Injury--diagnosis; Biomarkers--blood
Abstract
The context of a diagnostic test is a critical component for the interpretation of its result. This context defines the pretest probability of the diagnosis and forms the basis for the interpretation and value of adding the diagnostic test. In the field of acute kidney injury, a multitude of early diagnostic biomarkers have been developed, but utilization in the appropriate context is less well understood and has not been codified until recently. In order to better operationalize the context and pretest probability assessment for acute kidney injury diagnosis, the renal angina concept was proposed in 2010 for use in both children and adults. Renal angina has been assessed in approximately 1,000 subjects. However, renal angina as a concept is still unfamiliar to most clinicians and the rationale for introducing the term is not obvious. We therefore review the concept and development of renal angina, and the currently available data validating it. We discuss the various arguments for and against this construct. Future research testing the performance of renal angina with acute kidney injury biomarkers is warranted.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Chawla, L.S., Goldstein, S.L., Kellum, J.A., Ronco, C. (2015). Renal angina: concept and development of pretest probability assessment in acute kidney injury. Critical Care, 19:93. http://dx.doi.org/10.1186/s13054-015-0779-y
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of BioMed Central. Critical Care.