Fibrosis: Shared Lessons From the Lens and Cornea.
Document Type
Journal Article
Publication Date
6-1-2020
Journal
Anat Rec (Hoboken)
Volume
303
Issue
6
DOI
10.1002/ar.24088
Keywords
cornea; fibrocyte; fibrosis; lens; myofibroblast
Abstract
Regenerative repair in response to wounding involves cell proliferation and migration. This is followed by the reestablishment of cell structure and organization and a dynamic process of remodeling and restoration of the injured cells' extracellular matrix microenvironment and the integration of the newly synthesized matrix into the surrounding tissue. Fibrosis in the lungs, liver, and heart can lead to loss of life and in the eye to loss of vision. Learning to control fibrosis and restore normal tissue function after injury repair remains a goal of research in this area. Here we use knowledge gained using the lens and the cornea to provide insight into how fibrosis develops and clues to how it can be controlled. The lens and cornea are less complex than other tissues that develop life-threatening fibrosis, but they are well characterized and research using them as model systems to study fibrosis is leading toward an improved understanding of fibrosis. Here we summarize the current state of the literature and how it is leading to promising new treatments. Anat Rec, 2019. © 2019 The Authors. The Anatomical Record published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists.
APA Citation
Menko, A., Walker, J., & Stepp, M. (2020). Fibrosis: Shared Lessons From the Lens and Cornea.. Anat Rec (Hoboken), 303 (6). http://dx.doi.org/10.1002/ar.24088
Peer Reviewed
1
Open Access
1
Comments
This is an open access PubMed Central article.