The m.11778 A > G variant associated with the coexistence of Leber's hereditary optic neuropathy and multiple sclerosis-like illness dysregulates the metabolic interplay between mitochondrial oxidative phosphorylation and glycolysis.

Authors

Martine Uittenbogaard, George Washington University
Christine A. Brantner, George Washington University
ZiShui Fang
Lee-Jun Wong
Andrea Gropman, George Washington University
Anne Chiaramello, George Washington University

Document Type

Journal Article

Publication Date

5-1-2019

Journal

Mitochondrion

Volume

46

Inclusive Pages

187-194

DOI

10.1016/j.mito.2018.06.001

Keywords

Adult; DNA, Mitochondrial; Female; Fibroblasts; Glycolysis; Humans; Mitochondria; Multiple Sclerosis; Optic Atrophy, Hereditary, Leber; Oxidative Phosphorylation; Point Mutation

Comments

Epub 2018 Jun 8

APA Citation

Uittenbogaard, M., Brantner, C. A., Fang, Z., Wong, L., Gropman, A., & Chiaramello, A. (2019). The m.11778 A > G variant associated with the coexistence of Leber's hereditary optic neuropathy and multiple sclerosis-like illness dysregulates the metabolic interplay between mitochondrial oxidative phosphorylation and glycolysis.. Mitochondrion, 46 (). http://dx.doi.org/10.1016/j.mito.2018.06.001

Peer Reviewed

1