Title

The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation

Authors

Abbot R. Laptook, Department of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, USA. alaptook@wihri.org.
Lina Chalak, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Athina Pappas, Department of Pediatrics, Wayne State University, Detroit, MI, USA.
Alexis Davis, Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
Pablo J. Sanchez, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State College of Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Krisa P. Van Meurs, Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
William Oh, Department of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, USA.
Ross Sommers, Neonatology, Wellington Medical Center, Boca Raton, FL, USA.
Seetha Shankaran, Department of Pediatrics, Wayne State University, Detroit, MI, USA.
Angelita M. Hensman, Department of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, USA.
Dwight J. Rouse, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Women and Infants Hospital, Brown University, Providence, RI, USA.
Scott McDonald, Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle, NC, USA.
Abhik Das, Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, USA.
Ronald N. Goldberg, Department of Pediatrics, Duke University, Durham, NC, USA.
Namasivayam Ambalavanan, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Cynthia Gyamfi-Bannerman, Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.
Elizabeth A. Thom, Department of Biostatistics and Bioinformatics, George Washington University, Washington, DC, USA.
Rosemary D. Higgins, Department of Global and Community Health, George Mason University, Fairfax, VA, USA.

Document Type

Journal Article

Publication Date

5-26-2022

Journal

Journal of perinatology : official journal of the California Perinatal Association

DOI

10.1038/s41372-022-01415-4

Abstract

OBJECTIVE: Assess if maternal betamethasone administration at 34-35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation. STUDY DESIGN: Nested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 34-35 weeks gestation before 72 h (aEEG 1) and at 5-7 days (aEEG 2) if hospitalized. Personnel and aEEG central readers were masked to the intervention. The primary outcome was maturation reflected by cycle frequency; secondary outcomes were border voltage, span, and discontinuity. RESULTS: 58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had a greater lower border voltage and a broader span. On aEEG 2, both groups displayed increases in lower border voltage. CONCLUSIONS: Betamethasone associated changes in lower border voltage support accelerated electrical activity. Further investigation is needed to understand the broader span.

Department

Biostatistics and Bioinformatics

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