The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation
Journal of perinatology : official journal of the California Perinatal Association
OBJECTIVE: Assess if maternal betamethasone administration at 34-35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation. STUDY DESIGN: Nested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 34-35 weeks gestation before 72 h (aEEG 1) and at 5-7 days (aEEG 2) if hospitalized. Personnel and aEEG central readers were masked to the intervention. The primary outcome was maturation reflected by cycle frequency; secondary outcomes were border voltage, span, and discontinuity. RESULTS: 58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had a greater lower border voltage and a broader span. On aEEG 2, both groups displayed increases in lower border voltage. CONCLUSIONS: Betamethasone associated changes in lower border voltage support accelerated electrical activity. Further investigation is needed to understand the broader span.
Laptook, Abbot R.; Chalak, Lina; Pappas, Athina; Davis, Alexis; Sanchez, Pablo J.; Van Meurs, Krisa P.; Oh, William; Sommers, Ross; Shankaran, Seetha; Hensman, Angelita M.; Rouse, Dwight J.; McDonald, Scott; Das, Abhik; Goldberg, Ronald N.; Ambalavanan, Namasivayam; Gyamfi-Bannerman, Cynthia; Thom, Elizabeth A.; and Higgins, Rosemary D., "The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation" (2022). GW Authored Works. Paper 912.
Biostatistics and Bioinformatics