The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation

Authors

• Abbot R. Laptook, Department of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, USA. alaptook@wihri.org.
• Lina Chalak, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
• Athina Pappas, Department of Pediatrics, Wayne State University, Detroit, MI, USA.
• Alexis Davis, Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
• Pablo J. Sanchez, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State College of Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
• Krisa P. Van Meurs, Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
• William Oh, Department of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, USA.
• Ross Sommers, Neonatology, Wellington Medical Center, Boca Raton, FL, USA.
• Seetha Shankaran, Department of Pediatrics, Wayne State University, Detroit, MI, USA.
• Angelita M. Hensman, Department of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, USA.
• Dwight J. Rouse, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Women and Infants Hospital, Brown University, Providence, RI, USA.
• Scott McDonald, Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle, NC, USA.
• Abhik Das, Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, USA.
• Ronald N. Goldberg, Department of Pediatrics, Duke University, Durham, NC, USA.
• Namasivayam Ambalavanan, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA.
• Cynthia Gyamfi-Bannerman, Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.
• Elizabeth A. Thom, Department of Biostatistics and Bioinformatics, George Washington University, Washington, DC, USA.
• Rosemary D. Higgins, Department of Global and Community Health, George Mason University, Fairfax, VA, USA.

Document Type

Journal Article

Publication Date

5-26-2022

Journal

Journal of perinatology : official journal of the California Perinatal Association

DOI

10.1038/s41372-022-01415-4

Abstract

OBJECTIVE: Assess if maternal betamethasone administration at 34-35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation. STUDY DESIGN: Nested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 34-35 weeks gestation before 72 h (aEEG 1) and at 5-7 days (aEEG 2) if hospitalized. Personnel and aEEG central readers were masked to the intervention. The primary outcome was maturation reflected by cycle frequency; secondary outcomes were border voltage, span, and discontinuity. RESULTS: 58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had a greater lower border voltage and a broader span. On aEEG 2, both groups displayed increases in lower border voltage. CONCLUSIONS: Betamethasone associated changes in lower border voltage support accelerated electrical activity. Further investigation is needed to understand the broader span.

APA Citation

Laptook, Abbot R.; Chalak, Lina; Pappas, Athina; Davis, Alexis; Sanchez, Pablo J.; Van Meurs, Krisa P.; Oh, William; Sommers, Ross; Shankaran, Seetha; Hensman, Angelita M.; Rouse, Dwight J.; McDonald, Scott; Das, Abhik; Goldberg, Ronald N.; Ambalavanan, Namasivayam; Gyamfi-Bannerman, Cynthia; Thom, Elizabeth A.; and Higgins, Rosemary D., "The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation" (2022). GW Authored Works. Paper 912.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/912

Department

Biostatistics and Bioinformatics