Fosmanogepix treatment for coccidioidomycosis under an expanded access program

Authors

• Stuart H. Cohen, University of California, Davis Medical Center, Sacramento, CA, USA.
• Paul Allyn, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
• Felicia C. Chow, University of California San Francisco, San Francisco, CA, USA.
• Jennifer Rathe, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
• Deepa D. Nanayakkara, City of Hope, Duarte, CA, USA.
• Gerald Hutfles, Kaiser Permanente Northwest, Portland, OR, USA.
• Tara Vijayan, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
• Ethan A. Smith, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
• Christopher F. Saling, Department of Infectious Disease, Mayo Clinic Arizona, Phoenix, AZ, USA.
• Dan Ilges, Department of Pharmacy, Mayo Clinic Arizona, Pheonix, AZ, USA.
• Haran T. Schlamm, HTS Pharma, San Diego, CA, USA.
• George R. Thompson, University of California, Davis Medical Center, Sacramento, CA, USA.

Document Type

Journal Article

Publication Date

4-21-2026

Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

DOI

10.1093/cid/ciag271

Keywords

Coccidioidomycosis; antifungal; expanded access program; fosmanogepix

Abstract

Coccidioidomycosis is an invasive fungal infection that can disseminate and cause severe disease. Fosmanogepix ("gepix"), a first-in-class antifungal available via expanded access (NCT06433128), was successful in 8/11 patients (meningitis, 6/8 [75%]; non-meningeal dissemination, 2/3 [66%]) and was well tolerated for a median treatment duration of 208 days.

APA Citation

Cohen, Stuart H.; Allyn, Paul; Chow, Felicia C.; Rathe, Jennifer; Nanayakkara, Deepa D.; Hutfles, Gerald; Vijayan, Tara; Smith, Ethan A.; Saling, Christopher F.; Ilges, Dan; Schlamm, Haran T.; and Thompson, George R., "Fosmanogepix treatment for coccidioidomycosis under an expanded access program" (2026). GW Authored Works. Paper 9028.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/9028

Department

Pediatrics