Molecular Testing Expansion and Utilization in Transfusion Medicine

Authors

• HyoJeong Han, Division of Hematology, Center for Cancer and Blood Disorders, Children's National Hospital; Division of Pathology & Laboratory Medicine, Children's National Hospital, 111 Michigan Avenue NW, WW-4, Suite 600, Washington, DC 20010, USA; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA. Electronic address: [email protected].
• Zaina Inam, Division of Hematology, Center for Cancer and Blood Disorders, Children's National Hospital; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
• Jennifer Webb, Division of Hematology, Center for Cancer and Blood Disorders, Children's National Hospital; Division of Pathology & Laboratory Medicine, Children's National Hospital, 111 Michigan Avenue NW, WW-4, Suite 600, Washington, DC 20010, USA; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Document Type

Journal Article

Publication Date

3-1-2026

Journal

Clinics in laboratory medicine

Volume

46

Issue

1

DOI

10.1016/j.cll.2025.10.008

Keywords

Alloimmunization; Antigen; Cell-free DNA; D variants; Genotype; Human leukocyte antigen; Next generation sequencing; Polymerase chain reaction

Abstract

Molecular testing can identify genetic variants and accurately predict both red blood cell and platelet antigens. Furthermore, these assays can process large number of samples with quick turnaround time, allowing the techniques to be used not only in patients but also in donors. By accurately identifying recipient and donor blood antigens, appropriately matched blood products can be issued, reducing the risk of alloimmunization. These techniques can also be applied to prenatal testing of cell free fetal DNA.

APA Citation

Han, HyoJeong; Inam, Zaina; and Webb, Jennifer, "Molecular Testing Expansion and Utilization in Transfusion Medicine" (2026). GW Authored Works. Paper 8966.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/8966

Department

Pediatrics