GLP-1RA use improves outcomes post partial nephrectomy in T2DM patients with RCC: A TriNetX study

Authors

• Sam Kwon, The George Washington University School of Medicine and Health Sciences Washington District of Columbia USA.
• Fiona Wardrop, The George Washington University School of Medicine and Health Sciences Washington District of Columbia USA.
• Diego Gonzalez, The George Washington University School of Medicine and Health Sciences Washington District of Columbia USA.
• Francis Ryan, The George Washington University School of Medicine and Health Sciences Washington District of Columbia USA.
• Liza Khutsishvili, The George Washington University School of Medicine and Health Sciences Washington District of Columbia USA.
• Rollins Turner, The George Washington University School of Medicine and Health Sciences Washington District of Columbia USA.
• Mohammad Ghassab Deameh, Faculty of Medicine Al-Balqa Applied University As-Salt Jordan.
• Michael J. Whalen, Department of Urology The George Washington University School of Medicine and Health Sciences Washington District of Columbia USA.

Document Type

Journal Article

Publication Date

2-1-2026

Journal

BJUI compass

Volume

7

Issue

2

DOI

10.1002/bco2.70169

Keywords

diabetes mellitus, type 2; glucagon‐like peptide‐1 receptor agonists; partial nephrectomy; postoperative outcomes; renal cell carcinoma

Abstract

OBJECTIVES: The purpose of this study is to investigate the impact of Glucagon-like peptide-1 receptor agonists (GLP-1RAs) use on 90-day postoperative outcomes and overall survival following partial nephrectomy (PN) for renal cell carcinoma (RCC), where type 2 diabetes mellitus (T2DM) is a common comorbidity. MATERIALS AND METHODS: The TriNetX database was used to retrospectively identify T2DM patients who underwent PN. Patients prescribed GLP-1RAs were identified and matched in a 1:1 ratio with control patients who were not prescribed GLP-1RAs based on baseline characteristics, comorbidities, metformin and insulin prescription, and renal function laboratory values. For 90-day postoperative adverse events, risk difference, risk ratio and odds ratio with 95% confidence intervals were calculated. Kaplan-Meier analysis, log-rank tests and multivariable Cox Proportional Hazards model were performed to measure the effect of GLP-1RAs use on overall survival. RESULTS: Use of GLP-1RAs was associated with lower odds of acute kidney injury (odds ratio [OR] = 0.712), arrhythmia (OR = 0.725), readmission (OR = 0.8) and ileus (OR = 0.336) compared to the non-GLP-1RAs group (p < 0.05 for each). Kaplan-Meier analysis and log-rank tests demonstrated improved 2-year (p = 0.002) and 3-year (p = 0.001) overall survival among patients prescribed GLP-1RAs compared to those who were not. CONCLUSION: Use of GLP-1RAs was associated with reduced incidence of 90-day postoperative complications, such as acute kidney injury, arrhythmia, readmission and ileus, potentially contributing to improved overall survival. These results align with ongoing studies investigating the broader benefits of the use of GLP-1RAs.

APA Citation

Kwon, Sam; Wardrop, Fiona; Gonzalez, Diego; Ryan, Francis; Khutsishvili, Liza; Turner, Rollins; Deameh, Mohammad Ghassab; and Whalen, Michael J., "GLP-1RA use improves outcomes post partial nephrectomy in T2DM patients with RCC: A TriNetX study" (2026). GW Authored Works. Paper 8761.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/8761

Department

Urology