Structural and functional modifications of neuronal lipid rafts: implications for HIV-associated neurological disorders

Authors

• Ying Fu, Baker Heart and Diabetes Institute, Melbourne, VIC, 3187, Australia.
• Kevin Huynh, Baker Heart and Diabetes Institute, Melbourne, VIC, 3187, Australia.
• Nigora Mukhamedova, Baker Heart and Diabetes Institute, Melbourne, VIC, 3187, Australia.
• Ben Crossett, Sydney Mass Spectrometry, The University of Sydney, Camperdown, NSW, 2050, Australia.
• Denise Tran, Sydney Mass Spectrometry, The University of Sydney, Camperdown, NSW, 2050, Australia.
• Siera Martinez, McCormick Bioinformatics Core, Department of Biochemistry and Molecular Medicine, school of Medicine and Health Sciences, George Washington University, Washington, DC, 20037, USA.
• Anelia Horvath, McCormick Bioinformatics Core, Department of Biochemistry and Molecular Medicine, school of Medicine and Health Sciences, George Washington University, Washington, DC, 20037, USA.
• Hong-Yin Wang, Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, 22903, USA.
• Ivan Castello-Serrano, Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, 22903, USA.
• Rosanna Ippolitto, Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, 22903, USA.
• Farhad Parhami, MAX BioPharma Inc, Santa Monica, CA, 90404, USA.
• Peter J. Meikle, Baker Heart and Diabetes Institute, Melbourne, VIC, 3187, Australia.
• Ilya Levental, Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, 22903, USA.
• Michael Bukrinsky, Department of Microbiology, Immunology and Tropical Diseases, George Washington University, Washington, DC, 20037, USA.
• Dmitri Sviridov, Baker Heart and Diabetes Institute, Melbourne, VIC, 3187, Australia. Dmitri.Sviridov@Baker.edu.au.

Document Type

Journal Article

Publication Date

2-11-2026

Journal

Journal of neuroinflammation

DOI

10.1186/s12974-026-03730-5

Keywords

Extracellular vesicles; HIV; HIV-associated neurological disorder; Lipid rafts; Nef; Neurodegeneration; Neurons

APA Citation

Fu, Ying; Huynh, Kevin; Mukhamedova, Nigora; Crossett, Ben; Tran, Denise; Martinez, Siera; Horvath, Anelia; Wang, Hong-Yin; Castello-Serrano, Ivan; Ippolitto, Rosanna; Parhami, Farhad; Meikle, Peter J.; Levental, Ilya; Bukrinsky, Michael; and Sviridov, Dmitri, "Structural and functional modifications of neuronal lipid rafts: implications for HIV-associated neurological disorders" (2026). GW Authored Works. Paper 8729.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/8729

Department

Biochemistry and Molecular Medicine