A Subclinical Cytokine Storm is Present Before the Clinical Diagnosis of Amniotic Fluid Embolism: Implications for the Prediction and Prevention of Maternal Death

Authors

• Roberto Romero, Pregnancy Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland, USA; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, USA; George Washington University, School of Medicine and Health Sciences, Washington, DC, United States. Electronic address: romeror@mail.nih.gov.
• Arun Meyyazhagan, Pregnancy Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland, USA; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI; Department of Life Sciences, Christ University, Bengaluru, India.
• Dereje W. Gudicha, Pregnancy Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland, USA.
• Tinnakorn Chaiworapongsa, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.
• Awoniyi O. Awonuga, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.
• Adi L. Tarca, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI.
• Nardhy Gomez-Lopez, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI; Center for Reproductive Health Sciences, Departments of Obstetrics and Gynecology and Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
• Sonia S. Hassan, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI; Office of Women's Health, Integrative Biosciences Center, Wayne State University, Detroit, MI; Department of Physiology, Wayne State University School of Medicine, Detroit, MI.

Document Type

Journal Article

Publication Date

2-27-2026

Journal

American journal of obstetrics and gynecology

DOI

10.1016/j.ajog.2026.02.039

Keywords

Amniotic fluid embolism; DIC; IL-10; IL-6; IL-8; TNF-α; biomarkers; cardiovascular collapse; cytokine storm; hyperinflammation; immunomodulators; inflammation; maternal death

APA Citation

Romero, Roberto; Meyyazhagan, Arun; Gudicha, Dereje W.; Chaiworapongsa, Tinnakorn; Awonuga, Awoniyi O.; Tarca, Adi L.; Gomez-Lopez, Nardhy; and Hassan, Sonia S., "A Subclinical Cytokine Storm is Present Before the Clinical Diagnosis of Amniotic Fluid Embolism: Implications for the Prediction and Prevention of Maternal Death" (2026). GW Authored Works. Paper 8659.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/8659

Department

Obstetrics and Gynecology