Impact of preoperative biliary drainage on 30 Day outcomes of patients undergoing pancreaticoduodenectomy for malignancy

Authors

Gregor Werba, Department of Surgery, George Washington University, Washington, DC, USA. Electronic address: gwerba@gwu.edu.
Michael A. Napolitano, Department of Surgery, George Washington University, Washington, DC, USA.
Andrew D. Sparks, Department of Surgery, George Washington University, Washington, DC, USA.
Paul P. Lin, Department of Surgery, George Washington University, Washington, DC, USA.
Lynt B. Johnson, Department of Surgery, George Washington University, Washington, DC, USA.
Khashayar Vaziri, Department of Surgery, George Washington University, Washington, DC, USA.

Document Type

Journal Article

Publication Date

4-1-2022

Journal

HPB : the official journal of the International Hepato Pancreato Biliary Association

Volume

24

Issue

4

DOI

10.1016/j.hpb.2021.08.942

Abstract

BACKGROUND: Preoperative biliary drainage (PBD) has been advocated to address the plethora of physiologic derangements associated with cholestasis. However, available literature reports mixed outcomes and is based on largely outdated and/or single-institution studies. METHODS: Patients undergoing PBD prior to pancreaticoduodenectomy (PD) for periampullary malignancy between 2014-2018 were identified in the ACS-NSQIP pancreatectomy dataset. Patients with PBD were propensity-score-matched to those without PBD and 30-day outcomes compared. RESULTS: 8,970 patients met our inclusion criteria. 4,473 with obstruction and PBD were matched to 829 with no preoperative drainage procedure. In the non-jaundiced cohort, 711 stented patients were matched to 2,957 without prior intervention. PBD did not influence 30-day mortality (2.2% versus 2.4%) or major morbidity (19.8% versus 20%) in patients with obstructive jaundice. Superficial surgical site infections (SSIs) were more common with PBD (6.8% versus 9.2%), however, no differences in deep or organ-space SSIs were found. Patients without obstruction prior to PBD exhibited a 3-fold increase in wound dehiscence (0.5% versus 1.5%) additionally to increased superficial SSIs. CONCLUSION: PBD was not associated with an increase in 30-day mortality or major morbidity but increased superficial SSIs. PBD should be limited to symptomatic, profoundly jaundiced patients or those with a delay prior to PD.

APA Citation

Werba, Gregor; Napolitano, Michael A.; Sparks, Andrew D.; Lin, Paul P.; Johnson, Lynt B.; and Vaziri, Khashayar, "Impact of preoperative biliary drainage on 30 Day outcomes of patients undergoing pancreaticoduodenectomy for malignancy" (2022). GW Authored Works. Paper 860.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/860

Department

Surgery