Comments on "The effects of norepinephrine in shockable cardiac arrest, a scoping review"

Authors

Samantha Camp, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD, 21201, USA. samantha.camp@som.umaryland.edu.
Caitlin Williams, Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Ali Pourmand, Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Quincy K. Tran, Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Document Type

Journal Article

Publication Date

12-24-2025

Journal

Scandinavian journal of trauma, resuscitation and emergency medicine

Volume

33

Issue

1

DOI

10.1186/s13049-025-01508-x

Abstract

Norepinephrine in shockable cardiac arrest is a controversial topic. The review from Bouman et al. relies heavily on historical animal studies with limited human data, thus, their conclusion may not be clinically applicable. Current available data demonstrates significant heterogeneity, such as norepinephrine dosing and administration routes. Furthermore, a recent meta-analysis suggests no clear survival or neurologic benefit of norepinephrine over epinephrine. The assertions about neurologic outcomes, which were based on animal hemodynamics, were not supported by sufficient human evidence in the recent meta-analysis. Overall, the authors' conclusions may be too much of an overreach, due to given the variability and limitations of the included studies, warranting cautious interpretation.

APA Citation

Camp, Samantha; Williams, Caitlin; Pourmand, Ali; and Tran, Quincy K., "Comments on "The effects of norepinephrine in shockable cardiac arrest, a scoping review"" (2025). GW Authored Works. Paper 8361.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/8361

Department

School of Medicine and Health Sciences Resident Works