Effect of Sucralose on Cardiometabolic Health: A Review on Possible Mechanisms

Document Type

Journal Article

Publication Date

10-17-2025

Journal

Metabolic syndrome and related disorders

DOI

10.1177/15578518251389399

Keywords

Splenda; adipogenesis; appetite; endocrine dysfunction; gut dysbiosis; maternal consumption; nonnutritive sweeteners; obesity; satiety; sucralose

Abstract

Sucralose (a.k.a. Splenda when combined with dextrose and maltodextrin) is a popular nonnutritive sweetener (NNS) found in several beverages marketed for health benefits and fitness. This article examines the mechanistic aspects of sucralose's metabolic effects on satiety, obesity, glycemic control, and adipogenesis, along with gut dysbiosis, inflammation, and disruption of intestinal permeability. Some evidence suggests that sucralose may also alter appetite regulation, taste perception, and energy intake. Additionally, there are safety concerns regarding its carcinogenic potential and its epigenetic effect on the fetus due to consistent maternal consumption. Based on current findings of NNS, it was concluded that sucralose may be of use in weight reduction in the short term as an NNS. However, this needs to be weighed against the possible long-term metabolic side effects and safety precautions.

Department

Medicine

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