Accounting for social and environmental drivers of neurodevelopment: lessons from a pilot study in a pediatric Colombian cohort

Authors

Regan Andringa-Seed, Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA.
Laura Calderon Suarez, Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA. calderonlau@gmail.com.
Elizabeth Corn, Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA.
Heather Gordish-Dressman, Division of Biostatistics and Study Methodology, Children's National Hospital, Washington, DC, USA.
Meagan E. Williams, Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA.
Pablo Reyes, Department of Psychiatry and Mental Health, Hospital Universitario San Ignacio and Pontificia Universidad Javeriana Faculty of Medicine, Bogotá, Cundinamarca, Colombia.
Colleen Peyton, Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
Madison M. Berl, Division of Pediatric Neuropsychology, Children's National Hospital, Washington, DC, USA.
Margarita Arroyave-Wessel, Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA.
Michael E. Msall, Kennedy Research Center on Intellectual and Neurodevelopmental Disabilities, University of Chicago Comer Children's Hospital, Chicago, IL, USA.
Carlos Cure, BIOMELab SAS, Barranquilla, Atlántico, Colombia.
Sarah B. Mulkey, Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA.

Document Type

Journal Article

Publication Date

11-4-2025

Journal

Pediatric research

DOI

10.1038/s41390-025-04452-9

Abstract

BACKGROUND: Child neurodevelopment is shaped by complex social, environmental, and biological factors. Few studies have characterized these factors in Latin American populations. We aimed to evaluate the impact of social and environmental factors on neurodevelopmental outcomes in 5-6-year-old children from three geographic locations in Colombia. METHODS: Our pilot, cross-sectional study included 105 typically developing Colombian children from two urban cities and one rural municipality. Measures assessed domains of IQ (Wechsler Preschool and Primary Scale of Intelligence-WPPSI), executive functioning, psychosocial functioning, and a range of home environmental factors. We compared outcomes across locations and the impact of covariates using linear regression models. RESULTS: Including covariates, adjusted mean WPPSI IQ was significantly lower in children living in a rural town (80.41 ± 2.07) compared to either city (96.30 ± 2.76; 91.69 ± 2.90). Maternal education, location, dietary diversity, and home resources explained 46% of the variance in IQ. Outcomes in other domains were significantly different, but functioning was all within age expectations across groups. CONCLUSION: Significant disparities in cognitive and other outcomes exist among typically developing Colombian children, influenced by location, maternal education, and home resources. Future research should ensure well-matched control populations and use culturally appropriate, validated assessments to minimize social, cultural, and environmental confounding. IMPACT: Maternal education, dietary diversity, total home resources, and location account for approximately 50% of the neurodevelopmental variability of children from urban and rural Colombian cohorts. Typically developing children from a rural community in Colombia have a lower Full-Scale IQ than peers from urban cities, even after including multiple covariates. Future research should continue to study the multiple factors that impact neurodevelopment, particularly in low- and middle-income countries. Well-matched control populations and the use of culturally appropriate, validated assessments are important to minimize confounding factors in neurodevelopmental outcomes research, as statistical correction is not sufficient to fully account for these differences.

APA Citation

Andringa-Seed, Regan; Calderon Suarez, Laura; Corn, Elizabeth; Gordish-Dressman, Heather; Williams, Meagan E.; Reyes, Pablo; Peyton, Colleen; Berl, Madison M.; Arroyave-Wessel, Margarita; Msall, Michael E.; Cure, Carlos; and Mulkey, Sarah B., "Accounting for social and environmental drivers of neurodevelopment: lessons from a pilot study in a pediatric Colombian cohort" (2025). GW Authored Works. Paper 8146.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/8146

Department

Psychiatry and Behavioral Sciences