Hospital Variations in Time-To-Crisis-Resolution Among Children and Adolescents With Sickle Cell Disease

Chris A. Rees, Department of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Dunia Hatabah, Department of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Rawan Korman, Department of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Fahd Ahmad, Division of Pediatric Emergency Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Gladstone Airewele, Texas Children's Cancer and Hematology Centers, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA.
Bolanle Akinsola, Department of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Noor Alzraikat, Department of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Nitya Bakshi, Division of Pediatric Hematology-Oncology, Yale School of Medicine, New Haven, Connecticut, USA.
David C. Brousseau, Department of Pediatrics, Nemours Children's Health Delaware and the Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, Delaware, USA.
Kathleen Brown, Division of Emergency Medicine, Children's National Hospital and The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Andrew D. Campbell, Division of Emergency Medicine, Children's National Hospital and The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
T Charles Casper, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Todd P. Chang, Division of Pediatric Emergency Medicine, Children's Hospital Los Angeles and Keck School of Medicine of the University of Southern California, California, Los Angeles, USA.
Corrie E. Chumpitazi, Division of Emergency Medicine, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
Daniel Cohen, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Keli D. Coleman, Section of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin and Children's Wisconsin, Milwaukee, Wisconsin, USA.
Andrea T. Cruz, Texas Children's Cancer and Hematology Centers, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA.
Christopher Denton, Division of Pediatric Emergency Medicine, Children's Hospital Los Angeles and Keck School of Medicine of the University of Southern California, California, Los Angeles, USA.
Angela Ellison, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Melanie E. Fields, Division of Pediatric Emergency Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Monica Harding, Division of Pediatric Critical Care, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Sara Leibovich, Department of Emergency Medicine, University of California, San Francisco, California, USA.
Allison Remiker, Section of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin and Children's Wisconsin, Milwaukee, Wisconsin, USA.
Nidhi V. Singh, Texas Children's Cancer and Hematology Centers, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA.
Alexis A. Thompson, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Elliott Vichinsky, Center for Maternal-Fetal Precision Medicine, University of California, San Francisco, California, USA.
Anthony Villella, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Bridget Wynn, Department of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Carlton Dampier, Department of Pediatrics, Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Claudia R. Morris, Department of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Document Type

Letter to the Editor

Publication Date

11-5-2025

Journal

American journal of hematology

DOI

10.1002/ajh.70129

Keywords

arginine; sickle cell disease; sickle cell disease treatment with arginine therapy (STArT); time‐to‐crisis‐resolution; vaso‐occlusive pain episodes

Abstract

Analysis of the placebo cohort in the STArT trial shows that patient characteristics and hospital site strongly influence time-to-crisis-resolution and total opioid use in children and young adults with sickle cell disease, highlighting the need to account for these factors in the design of future clinical trials.

Department

Pediatrics

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